Flights
The closest airport to Eureka is in Arcata (ACV). It is about a 20 minute
drive from there to the Red Lion Hotel.
Red Lion has a limited seating shuttle service (call them directly to arrange pickup). You can also use a Taxi (about $70).
Car Rental may be limited availability and prices are about $350/week.
The local airport shuttle is Door-to-Door (about $35 for on person, plus $5 for each additional person - minivan holds 6). Reservations need to be made 3 days prior.
Flights to the Arcata airport are limited, so check availability and book early.
By Car
It is a 5 hour drive from the San Francisco Airport to Eureka, via Highway 101, but one should allow for 6 hours with rest stops and traffic.
It is a 5 hour drive from Sacramento, via Highway 5, then 20, then 101.
It is a 3 1/2 hour drive from the Redding Airport, via Highway 299 (Hwy 36 is not recommended unless you like twisty roads).